Sodium Hydroxide → 4,5,6,7-Tetrahydro-1,3-benzothiazole-5-carboxylic acid

HRID 1432351Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1432351
[OH-].[Na+].[S:3]1[C:7]2[CH2:8][CH2:9][CH:10]([C:12]([O:14]CC)=[O:13])[CH2:11][C:6]=2[N:5]=[CH:4]1>CO>[S:3]1[C:7]2[CH2:8][CH2:9][CH:10]([C:12]([OH:14])=[O:13])[CH2:11][C:6]=2[N:5]=[CH:4]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 13424804HCID 13424804, Verbindung

Produkt 1

HCID 685523074,5,6,7-Tetrahydro-1,3-benzothiazole-5-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

6 ml of 2N NaOH are added to a solution of 0.42 g of ethyl 4,5,6,7-tetrahydrobenzothiazole-5-carboxylate [952203-30-8] and 24 ml of MeOH at room temperature. After 6 hours, the reaction mixture is evaporated. The residue is acidified with 4N HCl, diluted with water and extracted with ethyl acetate (2×)—the combined organic phases are dried with sodium sulphate and evaporated. The crude title compound is obtained from the residue.

Aufarbeitung

  1. customthe reaction mixture is evaporated
  2. additiondiluted with water
  3. extractionextracted with ethyl acetate (2×)—the combined organic phases
  4. dry with materialare dried with sodium sulphate
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-2d395f3bf35e485a8aeafc3f85cc22c1
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612088B2

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