3-Fluorobenzaldehyde → N-(2-{2-[(3-Fluoro-phenyl)-(4-hydroxy-5-isopropyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-methyl]-1H-indol-3-yl}-ethyl)-acetamide

HRID 1432442

Reaktionsgleichung

Reaktionsgleichung von HRID 1432442
[OH:1][C:2]1[CH:6]([CH:7]([CH3:9])[CH3:8])[NH:5][C:4](=[O:10])[CH:3]=1.[F:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=1)[CH:15]=O.[NH:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:22]([CH2:29][CH2:30][NH:31][C:32](=[O:34])[CH3:33])=[CH:21]1>>[F:11][C:12]1[CH:13]=[C:14]([CH:15]([C:3]2[C:4](=[O:10])[NH:5][CH:6]([CH:7]([CH3:9])[CH3:8])[C:2]=2[OH:1])[C:21]2[NH:20][C:28]3[C:23]([C:22]=2[CH2:29][CH2:30][NH:31][C:32](=[O:34])[CH3:33])=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:17]=[CH:18][CH:19]=1

Komponenten

4

Edukt 3

HCID 680093-FluorobenzaldehydeHCID 70547N-AcetyltryptamineHCID 566041114-Hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one

Produkt 1

HCID 57933420N-(2-{2-[(3-Fluoro-phenyl)-(4-hydroxy-5-isopropyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-methyl]-1H-indol-3-yl}-ethyl)-acetamide

Versuchsvorschrift

Using general procedure C, 4-hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one (Lit. 11) was reacted with 3-fluoro-benzaldehyde and N-[2-(1H-indol-3-yl)-ethyl]-acetamide to give the title compound as a yellow solid. MS: 450.1 ([M+H]+).

Quellen und Nachweise

ORD-Eintrag
ord-ea6b15303856409899912449022a5da4
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612099B2

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