Benzaldehyde → N-(2-{2-[(4-hydroxy-5-isopropyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-phenyl-methyl]-1H-indol-3-yl}-ethyl)-3,5-bis-trifluoromethyl-benzamide

HRID 1432448

Reaktionsgleichung

Reaktionsgleichung von HRID 1432448
[OH:1][C:2]1[CH:6]([CH:7]([CH3:9])[CH3:8])[NH:5][C:4](=[O:10])[CH:3]=1.[CH:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[NH:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21]([CH2:28][CH2:29][NH:30][C:31](=[O:46])[C:32]2[CH:37]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:35]=[C:34]([C:42]([F:45])([F:44])[F:43])[CH:33]=2)=[CH:20]1>>[OH:1][C:2]1[CH:6]([CH:7]([CH3:9])[CH3:8])[NH:5][C:4](=[O:10])[C:3]=1[CH:11]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:20]1[NH:19][C:27]2[C:22]([C:21]=1[CH2:28][CH2:29][NH:30][C:31](=[O:46])[C:32]1[CH:33]=[C:34]([C:42]([F:43])([F:44])[F:45])[CH:35]=[C:36]([C:38]([F:41])([F:39])[F:40])[CH:37]=1)=[CH:23][CH:24]=[CH:25][CH:26]=2

Komponenten

4

Edukt 3

HCID 240BenzaldehydeHCID 22574444N-[2-(1H-Indol-3-yl)-ethyl]-3,5-bis-trifluoromethyl-benzamideHCID 566041114-Hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one

Produkt 1

HCID 57933450N-(2-{2-[(4-hydroxy-5-isopropyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-phenyl-methyl]-1H-indol-3-yl}-ethyl)-3,5-bis-trifluoromethyl-benzamide

Versuchsvorschrift

Using general procedure C, 4-hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one (Lit. 11) was reacted with benzaldehyde and N-[2-(1H-Indol-3-yl)-ethyl]-3,5-bis-trifluoromethyl-benzamide to give N-(2-{2-[(4-hydroxy-5-isopropyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-phenyl-methyl]-1H-indol-3-yl}-ethyl)-3,5-bis-trifluoromethyl-benzamide as a red solid. MS: 630.2 ([M+H]+).

Quellen und Nachweise

ORD-Eintrag
ord-417b4ab9312c43d89dd42747d9f42d32
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612099B2

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