HCID 17985179, Verbindung → HCID 67108942, Verbindung

HRID 1432946

Reaktionsgleichung

Reaktionsgleichung von HRID 1432946
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH2:12][N:13]3[CH2:18][CH2:17][NH:16][CH2:15][C:14]3=[O:19])[CH:8]=2)[N:3]=1.[Cl:20][C:21]1[S:25][C:24]([C:26]2[S:27][C:28]([S:31](Cl)(=[O:33])=[O:32])=[CH:29][CH:30]=2)=[CH:23][CH:22]=1>>[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH2:12][N:13]3[CH2:18][CH2:17][N:16]([S:31]([C:28]4[S:27][C:26]([C:24]5[S:25][C:21]([Cl:20])=[CH:22][CH:23]=5)=[CH:30][CH:29]=4)(=[O:32])=[O:33])[CH2:15][C:14]3=[O:19])[CH:8]=2)[N:3]=1

Komponenten

3

Edukt 2

HCID 17985179HCID 17985179, VerbindungHCID 220172805'-Chloro-2,2'-bithiophene-5-sulfonyl chloride

Produkt 1

HCID 67108942HCID 67108942, Verbindung

Versuchsvorschrift

The title compound is prepared as described in Example 101 using 1-(2-aminoquinolin-6-ylmethyl)piperazin-2-one, EXAMPLE 67, and 5′-chloro-[2,2′]bithiophenyl-5-sulfonyl chloride, EXAMPLE 2. The crude product is triturated in CH2Cl2 and filtered to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ7.82 (d, 1H), 7.68 (d, 1H), 7.42 (m, 3H), 7.36 (d, 1H), 7.25 (d, 1H), 7.20 (d, 1H), 6.70 (d, 1H), 6.43 (bs, 2H), 4.53 (s, 2H), 3.78 (s, 2H), 3.31 (m, 4H). MS (ion spray) m/z 519, 521, (M+H), Cl pattern.

Aufarbeitung

  1. customThe title compound is prepared
  2. customThe crude product is triturated in CH2Cl2
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-fc30cf20f9fd46eabde1851ccceb4328
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612075B2

Verknüpfte Notizen

Wird geladen…