6-Chlorobenzo[b]thiophene-2-sulfonyl chloride → HCID 69025875, Verbindung

HRID 1432947Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1432947
[O:1]=[C:2]1[CH2:7][NH:6][CH2:5][CH2:4][N:3]1[CH2:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14](=[O:19])[CH:13]=[CH:12]2.NC1C=CC2C(=CC=C(CN3CCNCC3=O)C=2)N=1.[Cl:39][C:40]1[CH:41]=[CH:42][C:43]2[CH:47]=[C:46]([S:48](Cl)(=[O:50])=[O:49])[S:45][C:44]=2[CH:52]=1>>[Cl:39][C:40]1[CH:41]=[CH:42][C:43]2[CH:47]=[C:46]([S:48]([N:6]3[CH2:5][CH2:4][N:3]([CH2:8][C:9]4[CH:10]=[C:11]5[C:16](=[CH:17][CH:18]=4)[NH:15][C:14](=[O:19])[CH:13]=[CH:12]5)[C:2](=[O:1])[CH2:7]3)(=[O:50])=[O:49])[S:45][C:44]=2[CH:52]=1

Komponenten

4

Edukt 3

HCID 151586416-Chlorobenzo[b]thiophene-2-sulfonyl chlorideHCID 179851791-(2-Aminoquinolin-6-ylmethyl)piperazin-2-oneHCID 57201358HCID 57201358, Verbindung

Produkt 1

HCID 69025875HCID 69025875, Verbindung

Versuchsvorschrift

The title compound is prepared as described in EXAMPLE 101,using 6-(2-oxopiperazin-1-ylmethyl)-1H-quinolin-2-one, minor product from EXAMPLE 67, Part D, and 6-chlorobenzo[b]thiophene-2-sulfonyl chloride, EXAMPLE 1. The crude product is triturated in CH2Cl2 and filtered to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ11.72 (bs, 1H), 8.33 (s, 1H), 8.18 (s, 1H), 8.07 (d, 1H), 7.78 (d, 1H), 7.58 (dd, 1H), 7.45 (s, 1H), 7.30 (dd, 1H), 7.18 (d, 1H), 6.46 (d, 1H), 4.52 (s, 2H), 3.86 (s, 2H), 3.43 (m, 2H), 3.31 (m, 2H). MS (ion spray) m/z 488, 490, (M+H), Cl pattern.

Aufarbeitung

  1. customThe title compound is prepared
  2. customThe crude product is triturated in CH2Cl2
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-5826fec45a6748d28ec1f98a0d767a1c
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612075B2

Notizen zur Reaktion

Wird geladen…