1-(4-Amino-quinazoline-7-ylmethyl)-3-methoxymethyl-piperazine-2-one → HCID 54022526, Verbindung

HRID 1432977Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1432977
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][NH:16][CH:15]([CH2:19][O:20][CH3:21])[C:14]3=[O:22])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.Br[CH2:24]/[CH:25]=[CH:26]/[C:27]1[S:28][C:29]([Cl:32])=[CH:30][CH:31]=1>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][N:16]([CH2:24][CH:25]=[CH:26][C:27]4[S:28][C:29]([Cl:32])=[CH:30][CH:31]=4)[C@@H:15]([CH2:19][O:20][CH3:21])[C:14]3=[O:22])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 179852231-(4-Amino-quinazoline-7-ylmethyl)-3-methoxymethyl-piperazine-2-oneHCID 217085162-(3-Bromo-(E)-propenyl)-5-chloro-thiophene

Produkt 1

HCID 54022526HCID 54022526, Verbindung

Versuchsvorschrift

The title compound is prepared as described in EXAMPLE 278 using 1-(4-amino-quinazoline-7-ylmethyl)-3-methoxymethyl-piperazine-2-one, EXAMPLE 75 and 2-(3-bromo-(E)-propenyl)-5-chloro-thiophene EXAMPLE 17. 1H NMR (d6-DMSO, 300 MHz) δ9.74 (bs, 2H), 8.80 (s, 1H), 8.38 (d, 1H), 7.69 (m, 2H), 7.02 (dd, 1H), 6.84 (d, 1H), 6.02 (m, 1H), 4.76 (AB, 2H), 3.86 (m, 4H), 3.30 (s, 3H), 3.23 (m, 2H), 3.02 (m, 2H). MS (ion spray), m/z, 458, 460, (M+H) (Cl pattern). Elemental analysis, cal C22H24ClN5O2S.2C2HF3O2.1.45H2O % C=43.85, % H=4.09, % N=9.83; found % C=43.92, % H=3.61, % N=9.63.

Quellen und Nachweise

ORD-Eintrag
ord-46b5df038a44420bb63d32360f1f50b1
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612075B2

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