Sodium Hydroxide → HCID 22936638, Verbindung

HRID 1433368Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1433368
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][CH2:16][C:17]([O:19]C)=[O:18])[N:9]=[CH:8][CH:7]=[C:6]2[O:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]([NH:31][C:32]2[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=2)=[O:30])=[CH:24][CH:23]=1)#[N:2].[OH-].[Na+]>CO>[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])[N:9]=[CH:8][CH:7]=[C:6]2[O:21][C:22]1[CH:23]=[CH:24][C:25]([NH:28][C:29]([NH:31][C:32]2[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=2)=[O:30])=[CH:26][CH:27]=1)#[N:2]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 10143024HCID 10143024, Verbindung

Produkt 1

HCID 22936638HCID 22936638, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

N-(4-(6-Cyano-7-(3-methoxycarbonylpropoxy)-4-quinolyl)oxyphenyl)-N′-(4-methoxyphenyl)urea (100 mg) was added to a methanol (16 ml) and 2N aqueous sodium hydroxide (3 ml) mixed solvent, and the mixture was heated and stirred at 80° C. for 35 minutes. The reaction solution was filtered, and then 1.2 ml of aqueous 5N hydrochloric acid was added. The precipitated solid was filtered out and washed with methanol and then ether to obtain 50 mg of the target substance as a light yellow solid.

Aufarbeitung

  1. additionmixed solvent
  2. temperaturethe mixture was heated
  3. filtrationThe reaction solution was filtered
  4. addition1.2 ml of aqueous 5N hydrochloric acid was added
  5. filtrationThe precipitated solid was filtered out
  6. washwashed with methanol
  7. customether to obtain 50 mg of the target substance as a light yellow solid

Quellen und Nachweise

ORD-Eintrag
ord-a11fc46b7ac14a07999fbccd8698ec23
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612092B2

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