4-Piperidinol, 1-methyl- → HCID 23087228, Verbindung

HRID 1433817Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1433817
[OH:1]C1CCN(C)CC1.FC1C=C(C=CC=1F)C#N.[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[C:23]#N>>[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[CH:23]=[O:1]

Komponenten

4

Edukt 3

HCID 660484-Piperidinol, 1-methyl-HCID 5872033,4-DifluorobenzonitrileHCID 230874123-Fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile

Produkt 1

HCID 23087228HCID 23087228, Verbindung

Versuchsvorschrift

Synthesized from 4-hydroxy-1-methylpiperidine and 3,4-difluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 3-fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile (1.1 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (1.1 g).

Aufarbeitung

  1. customwas used according to an analogous synthetic method to Preparation Example 16

Quellen und Nachweise

ORD-Eintrag
ord-230cd4b996c84e2fbb2af1b06b21455e
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612114B2

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