N-(2-chloroethyl)perhydroazepine hydrochloride → 1-{2-{4-[5-Methoxy-2-(6-methoxynaphthalen-2-yl)benzyl]phenoxy}ethyl}azepane

HRID 1433843Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1433843
OC1C=CC(C(C2C=C(OC)C=CC=2C2C=CC3C(=CC=C(OC)C=3)C=2)=O)=CC=1.Cl.ClCCN1CCCCCC1.[N:41]1([CH2:48][CH2:49][O:50][C:51]2[CH:56]=[CH:55][C:54]([C:57]([C:59]3[CH:64]=[C:63]([O:65][CH3:66])[CH:62]=[CH:61][C:60]=3[C:67]3[CH:76]=[CH:75][C:74]4[C:69](=[CH:70][CH:71]=[C:72]([O:77][CH3:78])[CH:73]=4)[CH:68]=3)=O)=[CH:53][CH:52]=2)[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1>>[CH3:66][O:65][C:63]1[CH:62]=[CH:61][C:60]([C:67]2[CH:76]=[CH:75][C:74]3[C:69](=[CH:70][CH:71]=[C:72]([O:77][CH3:78])[CH:73]=3)[CH:68]=2)=[C:59]([CH:64]=1)[CH2:57][C:54]1[CH:55]=[CH:56][C:51]([O:50][CH2:49][CH2:48][N:41]2[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47]2)=[CH:52][CH:53]=1

Komponenten

4

Edukt 3

HCID 24188283N-(2-chloroethyl)perhydroazepine hydrochlorideHCID 57933864(4-Hydroxyphenyl)[5-methoxy-2-(6-methoxynaphthalen-2-yl)phenyl]methanoneHCID 66626326[4-(2-Azepan-1-ylethoxy)phenyl][5-methoxy-2-(6-methoxynaphthalen-2-yl)phenyl]methanone

Produkt 1

HCID 666277861-{2-{4-[5-Methoxy-2-(6-methoxynaphthalen-2-yl)benzyl]phenoxy}ethyl}azepaneAusbeute 72 %

Versuchsvorschrift

Synthesized from (4-hydroxyphenyl)[5-methoxy-2-(6-methoxynaphthalen-2-yl)phenyl]methanone and 1-(2-chloroethyl)azepane hydrochloride according to an analogous synthetic method to Preparation Example 40, [4-(2-azepan-1-ylethoxy)phenyl][5-methoxy-2-(6-methoxynaphthalen-2-yl)phenyl]methanone (1.0 g) was used according to an analogous synthetic method to Example 337 described below to provide 1-{2-{4-[5-methoxy-2-(6-methoxynaphthalen-2-yl)benzyl]phenoxy}ethyl}azepane (700 mg). This compound (421 mg) was used according to an analogous synthetic method to Example 111 described below to provide the title compound (105 mg).

Quellen und Nachweise

ORD-Eintrag
ord-45bb189b119d48cdb55fb4933d78e4c6
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612114B2

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