3-[5-(2-Methylsulfanyl-pyrimidin-4-yl)-thiophen-2-yl]-4-nitro-butyric acid methyl ester → 4-[5-(2-Methylsulfanyl-pyrimidin-4-yl)-thiophen-2-yl]-pyrrolidin-2-one
Reaktionsgleichung
C[O:2][C:3](=O)[CH2:4][CH:5]([C:10]1[S:11][C:12]([C:15]2[CH:20]=[CH:19][N:18]=[C:17]([S:21][CH3:22])[N:16]=2)=[CH:13][CH:14]=1)[CH2:6][N+:7]([O-])=O>C(O)C.[Ni]>[CH3:22][S:21][C:17]1[N:16]=[C:15]([C:12]2[S:11][C:10]([CH:5]3[CH2:6][NH:7][C:3](=[O:2])[CH2:4]3)=[CH:14][CH:13]=2)[CH:20]=[CH:19][N:18]=1Komponenten
4
Versuchsvorschrift
The nitro derivative from Step B (100 mg, 0.283 mmol) was dissolved in 10 ml of ethanol and hydrogenated with Raney-nickel for 18 hours. The catalyst was then filtered off and the solution was heated to reflux for 3 hours. After evaporation, the crude product was purified by preparative HPLC. Yield: 19 mg (23%).