Thiophene-3-sulfonyl Chloride → [4-Amino-2-[1-(thiophene-3-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone

HRID 1435236

Reaktionsgleichung

Reaktionsgleichung von HRID 1435236
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])=[O:9])=[CH:6][N:5]=[C:4]([NH:19][CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[N:3]=1.[S:26]1[CH:30]=[CH:29][C:28]([S:31](Cl)(=[O:33])=[O:32])=[CH:27]1>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])=[O:9])=[CH:6][N:5]=[C:4]([NH:19][CH:20]2[CH2:21][CH2:22][N:23]([S:31]([C:28]3[CH:29]=[CH:30][S:26][CH:27]=3)(=[O:33])=[O:32])[CH2:24][CH2:25]2)[N:3]=1

Komponenten

3

Edukt 2

HCID 2776378Thiophene-3-sulfonyl ChlorideHCID 9997668[4-Amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone

Produkt 1

HCID 58777610[4-Amino-2-[1-(thiophene-3-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone

Versuchsvorschrift

The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone, Example 59, and 3-thiophenesulfonyl chloride (Maybridge) by the procedure described in Example 152. HR-MS (ES, m/z) calculated for C21H23FN5O4S2 [(M+H)+] 492.1170, observed 492.1175.

Quellen und Nachweise

ORD-Eintrag
ord-c85ca3cd9bf940e9a1b07c3c888dbfcf
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07615634B2

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