2-Bromo-1-ethoxy-4-fluorobenzene → (4-Amino-2-methylsulfanyl-pyrimidin-5-yl)-(2-ethoxy-5-fluoro-phenyl)-methanone
Reaktionsgleichung
CON(C)[C:4]([C:6]1[C:7]([NH2:15])=[N:8][C:9]([S:12][CH2:13]C)=[N:10][CH:11]=1)=[O:5].Br[C:18]1[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=1[O:25][CH2:26][CH3:27]>>[NH2:15][C:7]1[C:6]([C:4]([C:18]2[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=2[O:25][CH2:26][CH3:27])=[O:5])=[CH:11][N:10]=[C:9]([S:12][CH3:13])[N:8]=1Komponenten
3
Versuchsvorschrift
The compound was prepared from 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methyl-amide, Example 1, and 2-bromo-1-ethoxy-4-fluoro-benzene (prepared from 2-bromo-4-fluoro-phenol, Aldrich) in an analogous manner as described in Example 169.
Quellen und Nachweise
- ORD-Eintrag
- ord-8a8592ebd61849c481c60fbdcd7b88d3
- Quelldatensatz
- uspto-grants-2009_11
- DOI