[CH3:1][S:2][C:3]1[C:8]2[CH:9]=[C:10]([C:12]([O:14]C)=O)[NH:11][C:7]=2[CH:6]=[CH:5][N:4]=1.CC(C)([O-])C.[K+].[C:22]([O:26][CH3:27])(=[O:25])[CH:23]=[CH2:24]>C1(C)C=CC=CC=1>[CH3:1][S:2][C:3]1[C:8]2[CH:9]=[C:10]3[N:11]([C:7]=2[CH:6]=[CH:5][N:4]=1)[CH2:24][CH:23]([C:22]([O:26][CH3:27])=[O:25])[C:12]3=[O:14]To a suspension of methyl 4-(methylthio)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate (0.30 g, 1.35 mmol) in TBF (3 mL)-toluene (12.0 mL) were added a 1.06 M THE solution of potassium tert-butoxide (1.42 mL/1.41 mmol) and methyl acrylate (300 μL). The resulting mixture was heated at 80° C. for 18 h. The mixture was partitioned between EtOAc and NH4Cl, filtered through celite. The organic phase was separated, dried over Na2SO4 and filtered, to provide the title compound.
Wird geladen…
