Hydrochloric Acid → 2-Amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid methyl ester

HRID 1435943

Reaktionsgleichung

Reaktionsgleichung von HRID 1435943
[NH2:1][C@@H:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:14](=[O:22])[N:15]([CH3:21])[N:16]=[CH:17][C:18]=2[O:19][CH3:20])=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4].[CH3:23]OC(OC)(C)C.Cl>CO.O1CCOCC1>[CH3:23][O:4][C:3](=[O:5])[CH:2]([NH2:1])[CH2:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[C:14](=[O:22])[N:15]([CH3:21])[N:16]=[CH:17][C:18]=2[O:19][CH3:20])=[CH:11][CH:12]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 64952,2-DimethoxypropaneHCID 11536782(S)-2-Amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-di hydro-pyridazin-4-yl)-phenyl]-propionic acid

Produkt 1

HCID 690778032-Amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

2-(S)-Amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid (0.40 g, 1.0 mmol) was dissolved in MeOH (2.6 mL). Dimethoxypropane (0.26 mL) and 1N HCl in dioxane (0.33 mL) were added and stirred at room temperature for 24 h. The mixture was concentrated in vacuo to give 2-Amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid methyl ester. MS (ES+) 318.

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fefe75b7ab6e4f26b6cf7267ccd86610
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07618983B2

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