tert-Butyl (3S)-3-hydroxypyrrolidine-1-carboxylate → HCID 68875035, Verbindung
Reaktionsgleichung
C(OC([N:8]1[CH2:12][CH2:11][C@H:10]([OH:13])[CH2:9]1)=O)(C)(C)C.[NH2:14][C:15]1[C:24]2[C:19](=[CH:20][C:21](O)=[CH:22][CH:23]=2)[CH:18]=[CH:17][N:16]=1>>[NH:8]1[CH2:12][CH2:11][C@H:10]([O:13][C:21]2[CH:20]=[C:19]3[C:24](=[CH:23][CH:22]=2)[C:15]([NH2:14])=[N:16][CH:17]=[CH:18]3)[CH2:9]1Komponenten
3
Versuchsvorschrift
This compound was prepared from (S)-3-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester (195 mg, 1.04 mmol) and 1-amino-6-hydroxyisoquinoline (200 mg, 1.25 mmol) by the Mitsunobu procedure described in 3C, subsequent Boc deprotection according to procedure described in 3D gave (S)-6-(pyrrolidin-3-yloxy)-isoquinolin-1-ylamine, El-MS: m/z=230.3 [M+H]+.
Quellen und Nachweise
- ORD-Eintrag
- ord-c08d00961397459fa951d3dcd15037f1
- Quelldatensatz
- uspto-grants-2009_11