Phosphorus oxychloride → 5-Bromo-1-chloro-6-methoxyisoquinoline

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

POCl3 (6.5 ml) was added to the 5-bromo-6-methoxyisoquinoline-N-oxide hydrochloride (1.22 g) and the mixture heated at 90° C. for 6 h. Excess POCl3 was removed in vacuo and the remaining solid washed with water, filtered and dried in vacuo to give 5-bromo-1-chloro-6-methoxyisoquinoline (1.26 g).

Herkunft & Nachweise