Hydrochloride methanol → Hydrochloric Acid
Reaktionsgleichung
C(OC([NH:8][CH:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:27])=[CH:20][N:21]=[CH:22][C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.[ClH:28].CO>>[NH2:8][CH:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:27])=[CH:20][N:21]=[CH:22][C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1.[ClH:28]Komponenten
4
Versuchsvorschrift
Intermediate 1 (120 mg) prepared in Step A mentioned above is added with 10% hydrogen chloride/methanol (2 ml, Tokyo Kasei Kogyo), and the mixture is stirred at room temperature for 12 hours. The solvent is concentrated under reduced pressure, and the obtained solid is collected by filtration to obtain the title compound as hydrochloride (84 mg (predictive yield)).