HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-(Boc-amino)piperidine → Hydrochloric Acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-(Boc-amino)piperidine | HCID 4233041 | — |
| Edukt | 4-Chloroisoquinoline-5-sulfonyl chloride | HCID 22121908 | — |
| Produkt | Hydrochloric Acid | HCID 313 | 1.932,7% |
| Produkt | 3-(Tert-butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)piperidine | HCID 67242669 | — |
| Produkt | (r/s)-3-Amino-1-(4-chloro-5-isoquinolinesulfonyl)piperidine | HCID 67242690 | — |
Reaktionsschritte
(R/S)-3-(tert-Butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)-piperidine (Intermediate 18) is prepared from 4-chloro-5-isoquinolinesulfonyl chloride (183 mg) and 3-(tert-butoxycarbonylamino)piperidine (168 mg) according to the method described in Example 1, Step A, and then used in the method of Example 1, Step B in a similar manner to obtain the title compound as hydrochloride (164 mg (predictive yield)).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07618984B2 |
| Quelldatensatz | uspto-grants-2009_11 |
| ORD ID | ord-126c299982984ca3a1f4790663298875 |
| Quellennotiz | uspto-grants-2009_11 |