Hydrochloride methanol → Hydrochloric Acid

HRID 1436050Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1436050
C(OC([NH:8][CH:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Cl:28])=[CH:20][N:21]=[C:22]([NH2:27])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.[ClH:29].CO>>[NH2:8][CH:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Cl:28])=[CH:20][N:21]=[C:22]([NH2:27])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:15])=[O:16])[CH2:10]1.[ClH:29]

Komponenten

4

Edukt 2

HCID 21893726Hydrochloride methanolHCID 67243409(r/s)-3-(Tert-butoxycarbonyl)amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)-pyrrolidine

Produkt 2

HCID 313Hydrochloric AcidHCID 67242686(r/s)-3-Amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)pyrrolidine

Versuchsvorschrift

Intermediate 28 (30 mg) obtained in Step A mentioned above is added with 10% hydrogen chloride/methanol (4 ml), and the mixture is stirred at room temperature for 20 hours. The solvent is evaporated under reduced pressure to obtain the title compound as hydrochloride (25 mg (predictive yield)).

Aufarbeitung

  1. customThe solvent is evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-64145771ea8e43808e68985d8cdf132d
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07618984B2

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