Trifluoroacetic acid → (E)-5-chloro-2-{1-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylidene]valeric acid trifluoroacetate

HRID 1436139Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1436139
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].[Cl:8][CH2:9][CH2:10][CH2:11]/[C:12](=[CH:20]\[C:21]1[CH:26]=[CH:25][C:24]([N:27]2[CH:31]=[C:30]([CH3:32])[N:29]=[CH:28]2)=[C:23]([F:33])[CH:22]=1)/[C:13]([O:15]C(C)(C)C)=[O:14]>C(Cl)(Cl)Cl>[F:4][C:3]([F:6])([F:5])[C:1]([OH:7])=[O:2].[Cl:8][CH2:9][CH2:10][CH2:11]/[C:12](=[CH:20]\[C:21]1[CH:26]=[CH:25][C:24]([N:27]2[CH:31]=[C:30]([CH3:32])[N:29]=[CH:28]2)=[C:23]([F:33])[CH:22]=1)/[C:13]([OH:15])=[O:14]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 69004836HCID 69004836, Verbindung

Produkt 1

HCID 69003182(E)-5-chloro-2-{1-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylidene]valeric acid trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

chloroform (5 mL) and TFA (10 mL) were added to tert-butyl(E)-5-chloro-2-{1-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylidene}valerate (1.96 g), and the reaction solution was stirred at room temperature for one hour. The reaction solution was concentrated under reduced pressure. The residue was solidified with methylene chloride, ethyl acetate, and heptane and separated by filtration to obtain 2.19 g of the title compound. The property value of the compound is as follows.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customseparated by filtration

Quellen und Nachweise

ORD-Eintrag
ord-752a50c8bdae414a99ca8b585a0166d8
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07618960B2

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