4-(2,2,2-Trifluoroethoxy)benzonitrile → HCID 67500259, Verbindung
Reaktionsgleichung
F[C:2](F)(F)[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([CH:11]([NH2:13])[CH3:12])=[CH:7][CH:6]=1.FC(F)(F)CO[C:20]1[CH:27]=CC(C#N)=C[CH:21]=1>>[CH:3]1([O:4][C:5]2[N:10]=[CH:9][C:8]([CH:11]([NH2:13])[CH3:12])=[CH:7][CH:6]=2)[CH2:27][CH2:20][CH2:21][CH2:2]1Komponenten
3
Versuchsvorschrift
The title compound was synthesised according to the procedure described for the synthesis of 1-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethanamine, step B, starting from 4-(2,2,2-trifluoroethoxy)benzonitrile. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.28-7.34 (m, 2 H) 6.94-7.00 (m, 2 H) 4.70 (q, J=8.78 Hz, 2 H) 3.95 (q, J=6.53 Hz, 1 H) 1.21 (d, J=6.78 Hz, 3 H). MS (ESI) m/z: 220 [M+H]
Quellen und Nachweise
- ORD-Eintrag
- ord-918f17d928464ea7bb79fa00fd5977ee
- Quelldatensatz
- uspto-grants-2009_11