Hydrochloric Acid → HCID 91658617, Verbindung

HRID 1436376

Reaktionsgleichung

Reaktionsgleichung von HRID 1436376
[ClH:1].[CH2:2]([O:4][C:5]([C:7]1([NH:10]C(OC(C)(C)C)=O)[CH2:9][CH2:8]1)=[O:6])[CH3:3]>C(OCC)(=O)C>[Cl-:1].[CH2:2]([O:4][C:5]([C:7]1([NH3+:10])[CH2:9][CH2:8]1)=[O:6])[CH3:3]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 10242916Ethyl 1-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate

Produkt 1

HCID 91658617HCID 91658617, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

A saturated solution of HCl in ethyl acetate (20 mL) was added under nitrogen to a solution of 1-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopropane carboxylic acid ethyl ester (10.07 g, 43.9 mmol), prepared in the previous step, in 20 mL of ethyl acetate at room temperature. After the addition, the reaction was stirred at room temperature for 1 h. The solid present was collected by filtration, rinsed with ethyl acetate and dried under reduced pressure to give 1-ethoxycarbonyl-cyclopropyl-ammonium chloride as a white solid.

Aufarbeitung

  1. additionAfter the addition
  2. filtrationThe solid present was collected by filtration
  3. washrinsed with ethyl acetate
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-147f78c6847047b6a58b7ae09f3f9b92
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07618990B2

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