Hydrochloric Acid → Ethyl 5-(aminomethyl)-3-isoxazolecarboxylate

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Reaktionsgleichung

[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([CH2:11][NH:12]C(OC(C)(C)C)=O)[O:8][N:7]=1)=[O:5])[CH3:2].Cl>C(O)C.O1CCOCC1>[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([CH2:11][NH2:12])[O:8][N:7]=1)=[O:5])[CH3:2]

Komponenten

Reaktionsbedingungen

Temperatur: 20 °C

Versuchsvorschrift

To a stirred solution of 5-(tert-butoxycarbonylaminomethyl)-isoxazole-3-carboxylic acid ethyl ester (1.954 g) (EP 0451790) in ethanol (15 ml) was added a solution of 4.0M hydrogen chloride in 1,4-dioxane (23 ml). The mixture was stirred at 20° C. for 22 h and the solvent evaporated in vacuo to give the title compound (1.128 g) as a pale brown solid.

Aufarbeitung

customthe solvent evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-679b4847c7f54a819a20d8a5d5e8f9d4
Quelldatensatz: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07622464B2

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