1-(2-Methyl-2H-tetrazol-5-yl)methanamine → 1-{(2S)-4-[1-(3,4-Dichlorophenyl)ethyl]morpholin-2-ylmethyl}-3-(2-methyl-2H-tetrazol-5-ylmethyl)urea
Reaktionsgleichung
[CH3:1][N:2]1[N:6]=[N:5][C:4]([CH2:7][NH2:8])=[N:3]1.[Cl:9][C:10]1[CH:11]=[C:12]([CH:17]([N:19]2[CH2:24][CH2:23][O:22][C@@H:21]([CH2:25][NH:26][C:27](=O)[O:28]C3C=CC([N+]([O-])=O)=CC=3)[CH2:20]2)[CH3:18])[CH:13]=[CH:14][C:15]=1[Cl:16]>>[Cl:9][C:10]1[CH:11]=[C:12]([CH:17]([N:19]2[CH2:24][CH2:23][O:22][C@@H:21]([CH2:25][NH:26][C:27]([NH:8][CH2:7][C:4]3[N:5]=[N:6][N:2]([CH3:1])[N:3]=3)=[O:28])[CH2:20]2)[CH3:18])[CH:13]=[CH:14][C:15]=1[Cl:16]Komponenten
3
Versuchsvorschrift
Prepared in similar fashion to Example 16 but using C-(2-methyl-2H-tetrazol-5-yl)-methylamine and 4-nitrophenyl {(2S)-4-[1-(3,4-dichlorophenyl)ethyl]morpholin-2-yl}methylcarbamate Isomer II (prepared as described in WO 02/26723).
Aufarbeitung
- customPrepared in similar fashion to Example 16