(3,4-Dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methanol → 3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehyde

HRID 1437329

Reaktionsgleichung

Reaktionsgleichung von HRID 1437329
[S:1]1[CH2:6][CH2:5][NH:4][C:3]2[N:7]=[C:8]([CH2:11][OH:12])[CH:9]=[CH:10][C:2]1=2>ClCCl.[O-2].[O-2].[Mn+4]>[S:1]1[CH2:6][CH2:5][NH:4][C:3]2[N:7]=[C:8]([CH:11]=[O:12])[CH:9]=[CH:10][C:2]1=2

Komponenten

4

Edukt 1

HCID 18454501(3,4-Dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methanol

Produkt 1

HCID 184545003,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehydeAusbeute 50,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The alcohol (a) (0.482 g) in dry dichloromethane (50 ml) was stirred with manganese dioxide (1.2 g) for 18 hours and the mixture was filtered. The filtrate was evaporated and chomatographed on silica gel, eluting with methanol-dichloromethane (1:50) to afford a yellow solid (0.24 g).

Aufarbeitung

  1. filtrationthe mixture was filtered
  2. customThe filtrate was evaporated
  3. washeluting with methanol-dichloromethane (1:50)

Quellen und Nachweise

ORD-Eintrag
ord-e0ff8619783e438fb1a37a91f64277fb
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07622481B2

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