2,5-Dimethoxybenzyl alcohol → cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-1-(2,5-dimethoxybenzyl)-3-phenylpiperidine

HRID 1437642Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1437642
Cl.[F:2][C:3]([F:29])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][NH:12][CH2:11][C@H:10]1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[CH3:30][O:31][C:32]1[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][C:33]=1[CH2:34]O>>[F:29][C:3]([F:2])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:25])[F:26])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][N:12]([CH2:34][C:33]2[CH:36]=[C:37]([O:40][CH3:41])[CH:38]=[CH:39][C:32]=2[O:31][CH3:30])[CH2:11][C@H:10]1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Komponenten

3

Edukt 2

HCID 1184952,5-Dimethoxybenzyl alcoholHCID 86606807cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidine hydrochloride

Produkt 1

HCID 86606820cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-1-(2,5-dimethoxybenzyl)-3-phenylpiperidineAusbeute 23,8 %

Versuchsvorschrift

The compound (0.20 g) obtained in Example 1 and 2,5-dimethoxybenzyl alcohol (0.12 g) were reacted and treated in the same manner as in the method described in Example 16 to obtain the title compound as colorless oil (0.060 g, 23%).

Aufarbeitung

  1. additiontreated in the same manner as in the method

Quellen und Nachweise

ORD-Eintrag
ord-e54581387f2a4aa19380b4d168e09077
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07622487B2

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