Piperidine → 6-tert-Butyl-2-piperidin-1-ylnicotinonitrile

Reaktionsgleichung

[C:1]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7](Cl)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[C:1]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

Edukt 2

HCID 8082Piperidine

HCID 532788766-Tert-butyl-2-chloropyridine-3-carbonitrile

Produkt 1

HCID 588735266-tert-Butyl-2-piperidin-1-ylnicotinonitrileAusbeute 98 %

Versuchsvorschrift

A mixture of 6-tert-butyl-2-chloronicotinonitrile (Tetrahedron 1965, 21, 2453-2467, 1.5 g, 7.7 mmol) and piperidine (15 ml, 176 mmol) was stirred for 20 hours at room temperature. Then the reaction mixture was evaporated to remove piperidine in vacuo to give the title compound (1.8 g, 98%).

Aufarbeitung

customThen the reaction mixture was evaporated
customto remove piperidine in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-80d446bf3b074083b1f562d054f90ae1
Quelldatensatz: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07622589B2

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