2-Chloro-6,7-dimethoxy-4-quinazolinamine → 4-Amino-2-[4-(cyclopropylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline
Reaktionsgleichung
[CH:1]1([C:4]([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)=[O:5])[CH2:3][CH2:2]1.Cl[C:13]1[N:22]=[C:21]([NH2:23])[C:20]2[C:15](=[CH:16][C:17]([O:26][CH3:27])=[C:18]([O:24][CH3:25])[CH:19]=2)[N:14]=1>>[NH2:23][C:21]1[C:20]2[C:15](=[CH:16][C:17]([O:26][CH3:27])=[C:18]([O:24][CH3:25])[CH:19]=2)[N:14]=[C:13]([N:9]2[CH2:10][CH2:11][N:6]([C:4]([CH:1]3[CH2:2][CH2:3]3)=[O:5])[CH2:7][CH2:8]2)[N:22]=1Komponenten
3
Versuchsvorschrift
N-(Cyclopropylcarbonyl)piperazine (3.08 g., 0.02 mole) and 2-chloro-4-amino-6,7-dimethoxyquinazoline (4.74 g., 0.02 mole) are reacted according to the procedure of Example 1(a). The crude product crystallized from ethanol affords analytically pure 4-amino-2-[4-(cyclopropylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline, m.p. 283.5°-285.5° C. (corr.).
Aufarbeitung
- customThe crude product crystallized from ethanol