Thionyl Chloride → HCID 19973449, Verbindung

HRID 1440244Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1440244
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH2:10]O)=[CH:6][N:5]2[CH:12]=1.S(Cl)([Cl:15])=O>C(Cl)(Cl)Cl>[ClH:15].[Cl:15][CH2:10][C:7]1[CH:8]=[CH:9][C:4]2[N:5]([CH:12]=[C:2]([CH3:1])[N:3]=2)[CH:6]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 19973434HCID 19973434, Verbindung

Produkt 1

HCID 19973449HCID 19973449, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

6.80 g of the 2-methylimidazo[1,2-a]pyridine-6-methanol prepared in the Preparative Example 16 was dissolved in 90 ml of chloroform, followed by the dropwise addition of 6.1 ml of thionyl chloride under stirring at room temperature. After 2 hours, the solvent was distilled off. Crude 6-chloromethyl-2-methylimidazo-[1,2-a]pyridine hydrochloride was obtained as a brown oil.

Aufarbeitung

  1. distillationthe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-ac7b6567428d4b3d9a3f0e2f323b612b
Quelldatensatz
uspto-grants-1996_03
Patentnummer
US05498634

Notizen zur Reaktion

Wird geladen…