Acetyl chloride → (2R,5S)-1-Acetyl-2,5-dimethyl-4-(4-nitrophenyl)piperazine

HRID 1441360Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1441360
[CH3:1][C@H:2]1[CH2:7][NH:6][C@H:5]([CH3:8])[CH2:4][N:3]1[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1.[C:18](Cl)(=[O:20])[CH3:19]>>[C:18]([N:6]1[CH2:7][C@H:2]([CH3:1])[N:3]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)[CH2:4][C@H:5]1[CH3:8])(=[O:20])[CH3:19]

Komponenten

3

Edukt 2

HCID 6367Acetyl chlorideHCID 57664370(2S,5R)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine

Produkt 1

HCID 68686760(2R,5S)-1-Acetyl-2,5-dimethyl-4-(4-nitrophenyl)piperazine

Versuchsvorschrift

The title compound was prepared from (2S,5R)-2,5-dimethyl-1-(4-nitrophenyl)piperazine (Method 28, 8.22 g, 34.95 mmol) and acetyl chloride (4.5 ml, 62.91) by the procedure of Method 26. It was obtained as an oil which solidified on standing overnight (11.39 g, >100%, contaminated with solvent) NMR (400 MHz) 1.13 (m, 6H), 3.07 (m, 1H), 3.33 (m, 1H), 3.68 (m, 1H), 4.25 (m, 2H), 4.69 (m, 1H), 7.00 (d, 2H), 8.05 (d, 2H); m/z 278.

Aufarbeitung

  1. customIt was obtained as an oil which

Quellen und Nachweise

ORD-Eintrag
ord-9c492de619204a849626a739f798695f
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07655652B2

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