HCID 68537658, Verbindung → HCID 68540296, Verbindung

HRID 1442385Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1442385
[C:1]([O:4][C@@H:5]1[C@@H:10]([O:11][C:12](=[O:14])[CH3:13])[C@H:9]([O:15][C:16](=[O:18])[CH3:17])[C@@H:8]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[O:7][C@H:6]1[O:24][C:25]1[C:29]([CH2:30][C:31]2[CH:36]=[CH:35][C:34]([O:37][CH2:38][C:39]([C:42]([O:44]CC3C=CC=CC=3)=[O:43])([CH3:41])[CH3:40])=[CH:33][CH:32]=2)=[C:28]([CH:52]([CH3:54])[CH3:53])[NH:27][N:26]=1)(=[O:3])[CH3:2]>CO.[C].[Pd]>[C:1]([O:4][C@@H:5]1[C@@H:10]([O:11][C:12](=[O:14])[CH3:13])[C@H:9]([O:15][C:16](=[O:18])[CH3:17])[C@@H:8]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[O:7][C@H:6]1[O:24][C:25]1[C:29]([CH2:30][C:31]2[CH:32]=[CH:33][C:34]([O:37][CH2:38][C:39]([C:42]([OH:44])=[O:43])([CH3:41])[CH3:40])=[CH:35][CH:36]=2)=[C:28]([CH:52]([CH3:54])[CH3:53])[NH:27][N:26]=1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 68537658HCID 68537658, Verbindung

Produkt 1

HCID 68540296HCID 68540296, VerbindungAusbeute 101,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

3-(2,3,4,6-Tetra-O-acetyl-β-D-glucopyranosyloxy)-4-{[4-(2-benzyloxycarbonyl-2-methylpropoxy)phenyl]methyl}-5-isopropy-1H-pyrazole (0.28 g) was dissolved in methanol (6 mL). To the solution was added 10% palladium-carbon powder (54 mg), and the mixture was stirred at room temperature under a hydrogen atmosphere overnight. The insoluble material was removed by filtration, and the solvent of the filtrate was removed under reduced pressure to give the title compound (0.25 g).

Aufarbeitung

  1. customThe insoluble material was removed by filtration
  2. customthe solvent of the filtrate was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-13451e51060d4386a81ca9720b673960
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07655632B2

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