5-aminoisoquinolin-1(2H)-one → (Rac.) 5-{[4-(4-chloro-3-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentylidene]amino}isoquinolin-1(2h)-one

Reaktionsgleichung

ClC1C=CC(C(C)(C)CC(O)(C(F)(F)F)C=O)=C(OC)C=1F.C(O[C:26](=O)[C:27]([C:43]([F:46])([F:45])[F:44])([OH:42])[CH2:28][C:29]([C:32]1[CH:37]=[CH:36][C:35]([Cl:38])=[C:34]([F:39])[C:33]=1[O:40][CH3:41])([CH3:31])[CH3:30])C.[NH2:48][C:49]1[CH:58]=[CH:57][CH:56]=[C:55]2[C:50]=1[CH:51]=[CH:52][NH:53][C:54]2=[O:59]>CC1C=CC=CC=1C.C(OCC)(=O)C.[Cl-].[Na+].O.CC([O-])C.CC([O-])C.CC([O-])C.CC([O-])C.[Ti+4]>[Cl:38][C:35]1[CH:36]=[CH:37][C:32]([C:29]([CH3:31])([CH3:30])[CH2:28][C:27]([OH:42])([C:43]([F:46])([F:44])[F:45])[CH:26]=[N:48][C:49]2[CH:58]=[CH:57][CH:56]=[C:55]3[C:50]=2[CH:51]=[CH:52][NH:53][C:54]3=[O:59])=[C:33]([O:40][CH3:41])[C:34]=1[F:39]