1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 178513637, Verbindung

HRID 1443392Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1443392
[C:1]1([C:7]2[N:8]=[C:9]([CH:12]3[CH2:17][CH2:16][CH2:15][CH2:14][NH:13]3)[NH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:18]([C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH:28]([NH:32][C:33]([O:35][CH2:36][CH:37]2[C:49]3[CH:48]=[CH:47][CH:46]=[CH:45][C:44]=3[C:43]3[C:38]2=[CH:39][CH:40]=[CH:41][CH:42]=3)=[O:34])[C:29](O)=[O:30])=[CH:23][CH:22]=1)(=[O:20])[NH2:19].O.OC1C2N=NNC=2C=CC=1.Cl.CN(C)CCCN=C=NCC>CN(C)C=O>[CH:48]1[C:49]2[CH:37]([CH2:36][O:35][C:33](=[O:34])[NH:32][CH:28]([CH2:27][C:24]3[CH:23]=[CH:22][C:21]([C:18](=[O:20])[NH2:19])=[CH:26][CH:25]=3)[C:29](=[O:30])[N:13]3[CH2:14][CH2:15][CH2:16][CH2:17][CH:12]3[C:9]3[NH:10][CH:11]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[N:8]=3)[C:38]3[C:43](=[CH:42][CH:41]=[CH:40][CH:39]=3)[C:44]=2[CH:45]=[CH:46][CH:47]=1

Komponenten

6

Edukt 4

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 69156963-(4-carbamoylphenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic AcidHCID 178420113HCID 178420113, VerbindungHCID 178526939HCID 178526939, Verbindung

Produkt 1

HCID 178513637HCID 178513637, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a mixture of 138 mg (0.5 mmol) of 2-(4-Phenyl-1H-imidazol-2-yl)-piperidine, 215 mg (0.5 mmol) of 3-(4-Carbamoyl-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid, 135 mg (1.0 mmol) of hydroxybenzotriazole hydrate, 115 mg (0.6 mmol) of 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride was added 2 mL of dimethylformamide. The resulting mixture was allowed to stir at room temperature under argon overnight. The mixture was then partitioned between ethyl acetate and water. The organic layer was separated, dried over MgSO4 and concentrated to a yellow oil which was used for the next step without further purification.

Aufarbeitung

  1. customThe mixture was then partitioned between ethyl acetate and water
  2. customThe organic layer was separated
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated to a yellow oil which
  5. customwas used for the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-5f179a578af94aedbfed511fac85286e
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07659402B2

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