HCID 178439403, Verbindung → CID 57687148

HRID 1443491Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1443491
Cl[C:2]1[N:11]=[C:10]([OH:12])[C:9]2[C:4](=[C:5]([CH3:15])[C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=1.[CH:16]([C:19]1[CH:23]=[CH:22][NH:21][N:20]=1)([CH3:18])[CH3:17]>>[OH:12][C:10]1[C:9]2[C:4](=[C:5]([CH3:15])[C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=[C:2]([N:21]2[CH:22]=[CH:23][C:19]([CH:16]([CH3:18])[CH3:17])=[N:20]2)[N:11]=1

Komponenten

3

Edukt 2

HCID 178439403HCID 178439403, VerbindungHCID 1784877522-chloro-7-methoxy-8-methyl-1H-quinazolin-4-one

Produkt 1

HCID 178487760CID 57687148Ausbeute 63,4 %

Reaktionsbedingungen

Temperatur
155 °C

Versuchsvorschrift

A mixture of 2-chloro-4-hydroxy-7-methoxy-8-methylquinazoline (140) (502 mg, 2.23 mmol) and 3-isopropylpyrazole (500 mg, 4.55 mmol) was heated at 155° C. for 10 min. Then, the reaction mixture was successively cooled down to room temperature, partitioned between CH2Cl2 and water, dried (Na2SO4) and evaporated. The residue was triturated in ether and filtered to give the title compound (422 mg, 63%) as white needles: m/z=299 (M+H)+.

Aufarbeitung

  1. temperatureThen, the reaction mixture was successively cooled down to room temperature
  2. custompartitioned between CH2Cl2 and water
  3. dry with materialdried (Na2SO4)
  4. customevaporated
  5. customThe residue was triturated in ether
  6. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-bbfde6ba36554b468815b89bebe5adab
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07659245B2

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