Hydrazine → N-aminobenzenecarbothioamide

HRID 1443665

Reaktionsgleichung

Reaktionsgleichung von HRID 1443665
COC(=O)C[S:5][C:6](=S)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH2:15][NH2:16]>C(O)C>[C:6]([NH:15][NH2:16])(=[S:5])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 71356278Methyl 2-((phenylcarbonothioyl)thio)acetate

Produkt 1

HCID 3361911N-aminobenzenecarbothioamideAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Add a solution of thiobenzoylsulfanylacetic acid methyl ester (1.9 g, 8.4 mmol) in ethanol (30 mL) to a solution of anhydrous hydrazine (1 mL) at room temperature under nitrogen and stir for 2 hours. Then add water (20 mL) and remove the solvent under reduced pressure. Dissolve the residue in ethyl acetate (300 mL), wash with water (200 mL) and brine (200 mL), and dry over magnesium sulfate. Remove the solvent under reduced pressure to provide thiobenzoic acid hydrazide (1.2 g, 94%).

Aufarbeitung

  1. customThen add water (20 mL) and remove the solvent under reduced pressure
  2. dissolutionDissolve the residue in ethyl acetate (300 mL)
  3. washwash with water (200 mL) and brine (200 mL)
  4. dry with materialdry over magnesium sulfate
  5. customRemove the solvent under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-643fe99d9aef4473a01d8af06d2d8ee8
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07662771B2

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