3-Bromo-5-fluorobenzoic acid → [3-(3-Bromo-5-fluoro-benzoylamino)-phenyl]-acetic acid ethyl ester
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:11])[CH:10]=1)[C:5]([OH:7])=O.[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([NH2:23])[CH:18]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:5](=[O:7])[C:4]2[CH:3]=[C:2]([F:1])[CH:10]=[C:9]([Br:11])[CH:8]=2)[CH:18]=1)[CH3:13]Komponenten
3
Versuchsvorschrift
3-Fluoro-5-bromobenzoic acid (123 mg, 0.56 mmol) was coupled with ethyl ester (6) (100 mg, 0.56 mmol) following Method C to give the title compound.
Quellen und Nachweise
- ORD-Eintrag
- ord-ecb55fbe715f4d6cacd8b12cee4adc15
- Quelldatensatz
- uspto-grants-2010_02
- Patentnummer
- US07662839B2
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