Azido(trimethyl)stannane → HCID 178522031, Verbindung

Reaktionsgleichung

[C:1]([CH2:3][C:4]1[CH:5]=[C:6]([NH:10][C:11]([C:13]2[O:14][C:15]([Br:18])=[CH:16][CH:17]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1)#[N:2].[Sn]([N:23]=[N+:24]=[N-:25])(C)(C)C>>[NH:23]1[C:1]([CH2:3][C:4]2[CH:5]=[C:6]([NH:10][C:11]([C:13]3[O:14][C:15]([Br:18])=[CH:16][CH:17]=3)=[O:12])[CH:7]=[CH:8][CH:9]=2)=[N:2][N:25]=[N:24]1

Komponenten

Edukt 2

HCID 5104973Azido(trimethyl)stannane

HCID 596548595-Bromo-furan-2-carboxylic acid (3-cyanomethyl-phenyl)-amide

Produkt 1

HCID 178522031HCID 178522031, Verbindung

Versuchsvorschrift

Nitrile (83) (162 mg, 0.53 mmol) was treated with Me3SnN3 using Method K. The residue was purified by column chromatography, flushing with heptane (200 ml) and eluting with 50% EtOAc in heptane to give the title compound.

Aufarbeitung

customThe residue was purified by column chromatography
customflushing with heptane (200 ml)
washeluting with 50% EtOAc in heptane

Quellen und Nachweise

ORD-Eintrag: ord-2328271765a4498bb5ca149e8da0dae3
Quelldatensatz: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07662839B2

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