HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Fluorophenylboronic acid → 3-(3-{[6-(3-Fluoro-phenyl)-pyridine-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| Edukt | 3-{3-[(6-Bromo-pyridine-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester | HCID 72348809 | — |
| Produkt | 3-(3-{[6-(3-Fluoro-phenyl)-pyridine-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester | HCID 68497963 | — |
Reaktionsschritte
The pyridyl bromide (109) (100 mg, 0.27 mmol) was coupled to 3-fluoro-phenylboronic acid (41 mg, 0.29 mmol) using Method E. The residue was purified by column chromatography eluting with 20% EtOAc in heptane to give the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07662839B2 |
| Quelldatensatz | uspto-grants-2010_02 |
| ORD ID | ord-e63f3ff3c5c548d9b8296336abfb1d2d |
| Quellennotiz | uspto-grants-2010_02 |