3-Aminocinnamic acid ethyl ester → 3-(3-{[6-(4-Fluoro-phenyl)-pyridine-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester

HRID 1444364Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1444364
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH2:17]([O:19][C:20](=[O:30])[CH:21]=[CH:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([NH2:29])[CH:24]=1)[CH3:18]>>[CH2:17]([O:19][C:20](=[O:30])[CH:21]=[CH:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([NH:29][C:14]([C:12]2[CH:11]=[CH:10][CH:9]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[N:13]=2)=[O:16])[CH:24]=1)[CH3:18]

Komponenten

3

Edukt 2

HCID 978253-Aminocinnamic acid ethyl esterHCID 210817086-(4-Fluorophenyl)picolinic acid

Produkt 1

HCID 684969113-(3-{[6-(4-Fluoro-phenyl)-pyridine-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester

Versuchsvorschrift

Carboxylic acid (152) (50 mg, 0.23 mmol) was coupled to aniline (60) (44 mg, 0.23 mmol) using Method C. The crude residue was purified by column chromatography eluting with 10% EtOAc in heptane to give the title compound.

Aufarbeitung

  1. customThe crude residue was purified by column chromatography
  2. washeluting with 10% EtOAc in heptane

Quellen und Nachweise

ORD-Eintrag
ord-d5283ba721b34739a930503b4ce80fc2
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07662839B2

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