3-Fluorophenylboronic acid → (3-[(4,3'-Difluoro-biphenyl-3-carbonyl)-amino]-phenoxy}-acetic Acid Ethyl Ester

HRID 1444376

Reaktionsgleichung

Reaktionsgleichung von HRID 1444376
[CH2:1]([O:3][C:4](=[O:24])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:14](=[O:23])[C:15]2[CH:20]=[C:19](Br)[CH:18]=[CH:17][C:16]=2[F:22])[CH:8]=1)[CH3:2].[F:25][C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[CH:30][CH:31]=1>>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:14]([C:15]2[CH:20]=[C:19]([C:30]3[CH:29]=[CH:28][CH:27]=[C:26]([F:25])[CH:31]=3)[CH:18]=[CH:17][C:16]=2[F:22])=[O:23])[CH:8]=1)[CH3:2]

Komponenten

3

Edukt 2

HCID 27339863-Fluorophenylboronic acidHCID 40356283[3-(5-Bromo-2-fluoro-benzoylamino)-phenoxy]-acetic acid ethyl ester

Produkt 1

HCID 59654725(3-[(4,3'-Difluoro-biphenyl-3-carbonyl)-amino]-phenoxy}-acetic Acid Ethyl Ester

Versuchsvorschrift

The phenyl bromide (139) (100 mg, 0.25 mmol) was coupled to 3-fluoro-phenylboronic acid (34 mg, 0.24 mmol) using Method E. During this reaction, partial hydrolysis occurred. The residue was extracted using Work-up E1 to give a mixture of acid and ester, which was used without further purification.

Aufarbeitung

  1. customDuring this reaction, partial hydrolysis
  2. extractionThe residue was extracted
  3. customto give
  4. customwas used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-8844c3f3d732400b8926495427e5bad2
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07662839B2

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