Potassium Carbonate → 4-Piperidinopiperidine-1-carbonyl chloride

HRID 1444683

Reaktionsgleichung

Reaktionsgleichung von HRID 1444683
Cl.[N:2]1([CH:8]2[CH2:13][CH2:12][N:11]([C:14]([Cl:16])=[O:15])[CH2:10][CH2:9]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.C([O-])([O-])=O.[K+].[K+]>C(Cl)Cl>[N:2]1([CH:8]2[CH2:9][CH2:10][N:11]([C:14]([Cl:16])=[O:15])[CH2:12][CH2:13]2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 116375531-Chlorocarbonyl-4-piperidinopiperidine hydrochloride

Produkt 1

HCID 98133754-Piperidinopiperidine-1-carbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

[1,4′]bipiperidinyl-1′-carbonyl chloride hydrochloride (9.7 g), methylene chloride (150 ml) and K2CO3 (10.5 g, 2.1 ekv) were charged. The mixture was stirred for about 1 hour. The solution was filtered and the cake washed with 10 ml of methylene chloride. The solution (containing 8.4 g of [1,4′]bipiperidinyl-1′-carbonyl chloride) can be used as such for the preparation of Irinotecan

Aufarbeitung

  1. filtrationThe solution was filtered
  2. washthe cake washed with 10 ml of methylene chloride
  3. additionThe solution (containing 8.4 g of [1,4′]bipiperidinyl-1′-carbonyl chloride)
  4. customsuch for the preparation of Irinotecan

Quellen und Nachweise

ORD-Eintrag
ord-8b865cb372234e82bd5519d0c0b4537c
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07662964B2

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