Methanol → HCID 131727892, Verbindung

HRID 1444846Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1444846
[F:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=1.S(=O)(=O)(O)O.[CH3:28]O>>[CH3:28][O:10][C:9](=[O:11])[CH:8]([C:6]1[CH:7]=[C:2]([F:1])[C:3]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:20])([F:21])[F:22])=[CH:15][CH:14]=2)=[CH:4][CH:5]=1)[CH3:12]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 99727752-(2-Fluoro-4'-trifluoromethylbiphenyl-4-yl)propionic acid

Produkt 1

HCID 131727892HCID 131727892, VerbindungAusbeute 95 %

Versuchsvorschrift

A solution of 2-(2-fluoro-4′-trifluoromethylbiphenyl-4-yl)propionic acid (0.2 g, 0.64 mmoles) in methanol (3 ml) is added with 98% sulfuric acid (0.5 g) and refluxed for 2.5 hours. The solvent is removed under vacuum, the residue is taken up with ethyl acetate (5 ml) and washed with a 5% NaHCO3 solution (5 ml), then with water. The solution is dried over Na2SO4 and concentrated under vacuum to afford an oil (0.2 g, 95%).

Aufarbeitung

  1. temperaturerefluxed for 2.5 hours
  2. customThe solvent is removed under vacuum
  3. washwashed with a 5% NaHCO3 solution (5 ml)
  4. dry with materialThe solution is dried over Na2SO4
  5. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-89cb0fb3d1294c5ab572c427ec04c575
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07662995B2

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