Sodium Hydroxide → 2-Methylpyrimidine-5-carboxylic acid

HRID 1445472Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1445472
[OH-].[Na+].[CH3:3][C:4]1[N:9]=[CH:8][C:7]([C:10]([O:12]CC)=[O:11])=[CH:6][N:5]=1>C(O)C>[CH3:3][C:4]1[N:9]=[CH:8][C:7]([C:10]([OH:12])=[O:11])=[CH:6][N:5]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 14639203Ethyl 2-methylpyrimidine-5-carboxylate

Produkt 1

HCID 136708752-Methylpyrimidine-5-carboxylic acidAusbeute 78,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In 30 ml of ethanol and 20 ml of a 1M sodium hydroxide aqueous solution, 2.9 g of ethyl 2-methylpyrimidine-5-carboxylate was stirred for 2 hours. The solvent was removed by evaporation and an appropriate amount of water and diethyl ether were added thereto, followed by liquid-separating operation. The resulting aqueous layer was made weakly acidic with a 1M hydrochloric acid aqueous solution and then the resulting crystals were collected by filtration, washed with water, and then dried to obtain 1.9 g of the title compound.

Aufarbeitung

  1. customThe solvent was removed by evaporation
  2. additionan appropriate amount of water and diethyl ether were added
  3. customby liquid-separating operation
  4. filtrationthe resulting crystals were collected by filtration
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-872b3a9b5dd14914beb839c5b6da2b7c
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07666873B2

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