Potassium Fluoride → (E)-3-[1-(4-Ethynyl-benzenesulfonyl)-1H-pyrrol-3-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide

HRID 1445499Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1445499
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][NH:8][C:9](=[O:32])/[CH:10]=[CH:11]/[C:12]1[CH:16]=[CH:15][N:14]([S:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]#[C:27][Si](C)(C)C)=[CH:22][CH:21]=2)(=[O:19])=[O:18])[CH:13]=1.[F-].[K+]>CO>[C:26]([C:23]1[CH:24]=[CH:25][C:20]([S:17]([N:14]2[CH:15]=[CH:16][C:12](/[CH:11]=[CH:10]/[C:9]([NH:8][O:7][CH:2]3[CH2:3][CH2:4][CH2:5][CH2:6][O:1]3)=[O:32])=[CH:13]2)(=[O:19])=[O:18])=[CH:21][CH:22]=1)#[CH:27]

Komponenten

4

Edukt 2

HCID 522689Potassium FluorideHCID 86621703(E)-N-(Tetrahydro-pyran-2-yloxy)-3-[1-(4-trimethylsilanylethynyl-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylamide

Produkt 1

HCID 86621705(E)-3-[1-(4-Ethynyl-benzenesulfonyl)-1H-pyrrol-3-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a stirred solution of (E-N-(Tetrahydro-pyran-2-yloxy)-3-[1-(4-trimethylsilanylethynyl-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylamide (0.139 mmol) in methanol (1.2 ml) is added KF (0.26 mmol). After 15 min the solvent is evaporated and the residue is taken up in DCM and filtered over alumina (1 g, neutral, activity II-III) using DCM as eluent. After evaporation of the solvent 0.0801 mmol of the title compound are obtained.

Aufarbeitung

  1. customAfter 15 min the solvent is evaporated
  2. filtrationfiltered over alumina (1 g, neutral, activity II-III)

Quellen und Nachweise

ORD-Eintrag
ord-124081047e784fcfbc2ca9b155d5d5f7
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07666868B2

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