2-Chloro-4-fluorobenzaldehyde → 2-Chloro-4-(methylsulfonyl)benzaldehyde

HRID 1445596Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1445596
[Cl:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:11][S:12]([O-:14])=[O:13].[Na+]>CS(C)=O>[Cl:1][C:2]1[CH:9]=[C:8]([S:12]([CH3:11])(=[O:14])=[O:13])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

Komponenten

4

Edukt 2

HCID 1450242-Chloro-4-fluorobenzaldehydeHCID 2733271Sodium methanesulfinate

Produkt 1

HCID 27610842-Chloro-4-(methylsulfonyl)benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

A suspension of 2-chloro-4-fluorobenzaldehyde (24.9 g, 0.16 mol) and dry sodium methanesulfinate (17.9 g, 0.175 mmol) in dry DMSO (60 ml) is stirred at 90° C. overnight. The reaction mixture is allowed to cool to room temperature and then poured onto ice-water (400 ml). The resulting precipitated is collected by filtration and dried under high vacuum to yield the titled compound as a yellow powder.

Aufarbeitung

  1. temperatureto cool to room temperature
  2. additionpoured onto ice-water (400 ml)
  3. customThe resulting precipitated
  4. filtrationis collected by filtration
  5. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-b5a05e877778479e85d4511b615722ee
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07666878B2

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