[F:1][C@H]1CCN(C(OC(C)(C)C)=O)C1.[C:14]([N:21]1[CH2:25][CH2:24][C@@H:23]([CH2:26]O)[CH2:22]1)([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15].COCCN(S(F)(F)F)CCOC>ClCCl>[F:1][CH2:26][C@@H:23]1[CH2:24][CH2:25][N:21]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:22]1Prepare using the method of Intermediate 48 with (R)-N-Boc-pyrrolidine-3-methanol (0.50 g, 2.48 mmol), [bis(2-methoxyethyl)amino]sulfur trifluoride (0.55 mL, 2.98 mmol) and anhydrous dichloromethane (2.5 mL) to give the title compound as a colourless oil (0.34 g): MS (m/e): 226 (M+23).
Wird geladen…