Methanesulfonic acid 2-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-ethyl ester → 2-(3-Fluoro-4'-methanesulfonyl-biphenyl-4-yl)-5-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole
Reaktionsgleichung
BrC1C=CC([C:8]2O[C:10](C)=[C:11]([CH2:13][CH2:14]OS(C)(=O)=O)[N:12]=2)=CC=1.[F:21][C:22]1[CH:23]=[C:24]([C:37]2[CH:42]=[CH:41][C:40]([S:43]([CH3:46])(=[O:45])=[O:44])=[CH:39][CH:38]=2)[CH:25]=[CH:26][C:27]=1[C:28]1[O:29][C:30]([CH3:36])=[C:31]([CH2:33][CH2:34]O)[N:32]=1>>[F:21][C:22]1[CH:23]=[C:24]([C:37]2[CH:38]=[CH:39][C:40]([S:43]([CH3:46])(=[O:45])=[O:44])=[CH:41][CH:42]=2)[CH:25]=[CH:26][C:27]=1[C:28]1[O:29][C:30]([CH3:36])=[C:31]([CH2:33][CH2:34][N:12]2[CH2:8][CH2:14][CH2:13][CH:11]2[CH3:10])[N:32]=1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The titled compound is prepared in substantial accordance with the procedures found in Intermediate 13 and Example 75 using 2-[2-(3-Fluoro-4′-methanesulfonyl-biphenyl-4-yl)-5-methyl-oxazol-4-yl]-ethanol (see Intermediate 38). MS (m/e): 443.3 (M+1)