Triethylamine → 1-benzyl-2-ethyl-1H-pyrrole

HRID 1445937

Reaktionsgleichung

Reaktionsgleichung von HRID 1445937
[C:1]1(C2C=CC=CC=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH2:13][CH3:14].C1(C2C=CC=CC=2)C=CC=CC=1CN.C(N(CC)CC)C>C1C=CC=CC=1>[CH2:7]([N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH2:13][CH3:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:1]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 2633661-Biphenyl-2-ylmethanamineHCID 591704071-(Biphenyl-2-ylmethyl)-2-ethyl-1h-pyrrole

Produkt 1

HCID 32494221-benzyl-2-ethyl-1H-pyrrole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

1-(biphenyl-2-ylmethyl)-2-ethyl-1H-pyrrole, 13: To the crude 12 (14 g, 83 mmol) in dry benzene (200 mL) at room temperature is added biphenyl-2-ylmethanamine solution (100 mmol) and triethylamine (110 mmol). The solution is heated to reach 65° C. and stirred for 18 h. The resulted reaction mixture is filtered and concentrated. The crude product was purified by silica gel chromatography to afford 13

Aufarbeitung

  1. temperatureThe solution is heated
  2. customto reach 65° C.
  3. customThe resulted reaction mixture
  4. filtrationis filtered
  5. concentrationconcentrated
  6. customThe crude product was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-6aecf2aef7954c0e9158959462e7c8ff
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07666898B2

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