Methyl(3-(4-methylpiperazin-1-yl)propyl)amine → HCID 68542076, Verbindung

HRID 1445998Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1445998
[CH3:1][C:2]([O:4][C@H:5]1[C:14]2[C@@:15]3([CH3:30])[C@@H:26]([CH2:27][O:28][CH3:29])[O:25][C:23](=[O:24])[C:17]4=[CH:18][O:19][C:20]([C:21](=[O:22])[C:13]=2[C@@H:8]2[CH2:9][CH2:10][C@H:11]([OH:12])[C@@:7]2([CH3:31])[CH2:6]1)=[C:16]34)=[O:3].[CH3:32][NH:33][CH2:34][CH2:35][CH2:36][N:37]1[CH2:42][CH2:41][N:40]([CH3:43])[CH2:39][CH2:38]1>C(Cl)Cl>[OH:19][C:20]1[C:21](=[O:22])[C:13]2[CH:8]3[C:7]([CH3:31])([CH:11]([OH:12])[CH2:10][CH2:9]3)[CH2:6][CH:5]([O:4][C:2](=[O:3])[CH3:1])[C:14]=2[C:15]2([CH3:30])[C:16]=1[C:17](=[CH:18][N:33]([CH3:32])[CH2:34][CH2:35][CH2:36][N:37]1[CH2:38][CH2:39][N:40]([CH3:43])[CH2:41][CH2:42]1)[C:23](=[O:24])[O:25][CH:26]2[CH2:27][O:28][CH3:29]

Komponenten

4

Edukt 2

HCID 7219854Methyl(3-(4-methylpiperazin-1-yl)propyl)amineHCID 986734017beta-Hydroxy wortmannin

Produkt 1

HCID 68542076HCID 68542076, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 100 mg (0.23 mmol) 17-hydroxywortmannin in 2 mL CH2Cl2 is added methyl-[3-(4-methyl-piperazine-1-yl)propyl]amine (80 mg, 0.46 mmol). The reaction mixture is stirred at room temperature for 12 hours and then concentrated in vacuo. The residue is dissolved in EtOAc and precipitated with hexane. The precipitate is washed two times with hexane to give the product as a yellow solid. MS (ESI) m/z 603 (M+H).

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue is dissolved in EtOAc
  3. customprecipitated with hexane
  4. washThe precipitate is washed two times with hexane

Quellen und Nachweise

ORD-Eintrag
ord-6903463a6c3d49c38d2fa0c9da7d1e2b
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07666901B2

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