Pyrrolidine → HCID 24809923, Verbindung

Reaktionsgleichung

[C:1]1([C:7]2[O:11][N:10]=[CH:9][C:8]=2[C:12]([OH:14])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[C:1]1([C:7]2[O:11][N:10]=[CH:9][C:8]=2[C:12]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[O:14])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

Edukt 2

HCID 31268Pyrrolidine

HCID 147872535-Phenylisoxazole-4-carboxylic acid

Produkt 1

HCID 24809923HCID 24809923, Verbindung

Versuchsvorschrift

The title compound was prepared from 5-(phenyl)isoxazole-4-carboxylic acid (9.5 mg, 0.050 mmol) and pyrrolidine (4.3 mg, 0.060 mmol) as described in synthetic method A and thereafter purified, first by preparative HPLC method A and then by method B, to give a solid (12.9 mg). MS (pos) m/z 243.2 (M+H).

Aufarbeitung

custompurified, first by preparative HPLC method A

Quellen und Nachweise

ORD-Eintrag: ord-4c7c64cd7b4b4cebb0c95c41be6364ce
Quelldatensatz: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07666888B2

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